DNAJC15
Function
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Involvement in disease
Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Tissue Specificity
Expressed at highest levels in heart, followed by liver and kidney.
Cellular localization
- Mitochondrion inner membrane
- Single-pass membrane protein
Alternative names
DNAJD1, GIG22, HSD18, DNAJC15, DnaJ homolog subfamily C member 15, Cell growth-inhibiting gene 22 protein, Methylation-controlled J protein, MCJ