DNAJC2
Domain
The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
Function
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
Post-translational modifications
Phosphorylated in M (mitotic) phase.
Tissue Specificity
Widely expressed.
Cellular localization
- Nucleus
- Cytoplasm
- Cytosol
Alternative names
MPHOSPH11, MPP11, ZRF1, DNAJC2, DnaJ homolog subfamily C member 2, M-phase phosphoprotein 11, Zuotin-related factor 1