DNAJC24
Domain
The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.
Function
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Pathway
Protein modification; peptidyl-diphthamide biosynthesis.
Sequence Similarities
Belongs to the DPH4 family.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
DPH4, ZCSL3, DNAJC24, DnaJ homolog subfamily C member 24, CSL-type zinc finger-containing protein 3, Diphthamide biosynthesis protein 4