dnaK
Function
Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.
Post-translational modifications
Autophosphorylated; GrpE inhibits the autophosphorylation.
Sequence Similarities
Belongs to the heat shock protein 70 family.
Cellular localization
- Cytoplasm
- Cell inner membrane
- Peripheral membrane protein
Alternative names
groP, grpF, seg, b0014, JW0013, dnaK, Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70