DOC2A
Domain
C2 domain 1 is involved in binding calcium and phospholipids.
Function
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Tissue Specificity
Predominantly expressed in brain. Also expressed in testis.
Cellular localization
- Lysosome
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Peripheral membrane protein
- Synapse
- Synaptosome
Alternative names
Double C2-like domain-containing protein alpha, Doc2, Doc2-alpha, DOC2A