DOC2B
Domain
C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes (By similarity).
Function
Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).
Tissue Specificity
Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
Cellular localization
- Cytoplasm
- Cytoplasmic granule
- Cell membrane
- Peripheral membrane protein
- Translocates to the plasma membrane in a calcium-dependent manner.
Alternative names
DOC2BL, DOC2B, Double C2-like domain-containing protein beta, Doc2-beta