DOCK10
Domain
The DOCKER domain may mediate some GEF activity.
Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
Sequence Similarities
Belongs to the DOCK family.
Tissue Specificity
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
Cellular localization
- Nucleus
- Cytoplasm
- Cell projection
- Dendritic spine
Alternative names
KIAA0694, ZIZ3, DOCK10, Dedicator of cytokinesis protein 10, Zizimin-3