DOCK5
Domain
The DOCKER domain may mediate some GEF activity.
Function
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
Sequence Similarities
Belongs to the DOCK family.
Cellular localization
- Cytoplasm
- Cell membrane
- Cell projection
- Podosome
- Associated with the edge of the plasma membrane in Caco-2 intestinal epithelial cells spreading on type IV collagen.
Alternative names
Dedicator of cytokinesis protein 5, DOCK5