DOCK9
Domain
The DOCKER domain is necessary and sufficient for the GEF activity.
Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
Sequence Similarities
Belongs to the DOCK family.
Tissue Specificity
Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.
Cellular localization
- Endomembrane system
- Associated with membranes.
Alternative names
KIAA1058, ZIZ1, DOCK9, Dedicator of cytokinesis protein 9, Cdc42 guanine nucleotide exchange factor zizimin-1, Zizimin-1