DOK5
Domain
PTB domain mediates receptor interaction.
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Post-translational modifications
Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
Sequence Similarities
Belongs to the DOK family. Type B subfamily.
Tissue Specificity
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Alternative names
C20orf180, DOK5, Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6