DOK6
Domain
PTB domain mediates receptor interaction.
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
Post-translational modifications
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
Sequence Similarities
Belongs to the DOK family. Type B subfamily.
Tissue Specificity
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
Alternative names
DOK5L, DOK6, Docking protein 6, Downstream of tyrosine kinase 6