DPEP1
Function
Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:31442408, PubMed:32325220, PubMed:6334084). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (PubMed:32325220). Possesses also beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem (PubMed:32325220, PubMed:6334084).
Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Tissue Specificity
Expressed in lung and kidneys.
Cellular localization
- Apical cell membrane
- Lipid-anchor
- GPI-anchor
- Cell projection
- Microvillus membrane
- Lipid-anchor
- GPI-anchor
- Brush border membrane.
Alternative names
MDP, RDP, DPEP1, Dipeptidase 1, Beta-lactamase, Dehydropeptidase-I, Microsomal dipeptidase, Renal dipeptidase, hRDP