DPEP2
Function
Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:32325220). Hydrolyzes cystinyl-bis-glycine (PubMed:32325220).
Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway.
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Cellular localization
- Membrane
- Lipid-anchor
- GPI-anchor
Alternative names
UNQ284/PRO323, DPEP2, Dipeptidase 2