DPM1
Function
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
Pathway
Protein modification; protein glycosylation.
Sequence Similarities
Belongs to the glycosyltransferase 2 family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Cytoplasmic side
Alternative names
SED3, YPR183W, P9705.3, DPM1, Dolichol-phosphate mannosyltransferase, Dolichol-phosphate mannose synthase, Dolichyl-phosphate beta-D-mannosyltransferase, Mannose-P-dolichol synthase, DPM synthase, MPD synthase