DPP10
Function
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
Involvement in disease
Asthma
ASTHMA
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.
Sequence Similarities
Belongs to the peptidase S9B family. DPPIV subfamily.
Tissue Specificity
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
DPRP3, KIAA1492, DPP10, Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPP X, DPL2