DR1
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Post-translational modifications
Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
Sequence Similarities
Belongs to the NC2 beta/DR1 family.
Cellular localization
- Nucleus
Alternative names
Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, TATA-binding protein-associated phosphoprotein, NC2-beta, DR1