The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
Belongs to the NC2 beta/DR1 family.
Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, TATA-binding protein-associated phosphoprotein, NC2-beta, DR1
Proteins
Neuroscience
19444Da
We found 5 products in 3 categories