DRAP1
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Post-translational modifications
Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.
Sequence Similarities
Belongs to the NC2 alpha/DRAP1 family.
Tissue Specificity
Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
Cellular localization
- Nucleus
Alternative names
Dr1-associated corepressor, Dr1-associated protein 1, Negative cofactor 2-alpha, NC2-alpha, DRAP1