DRAXIN
Function
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Sequence Similarities
Belongs to the draxin family.
Cellular localization
- Secreted
Alternative names
C1orf187, PSEC0258, UNQ3119/PRO10268, DRAXIN, Draxin, Dorsal inhibitory axon guidance protein, Dorsal repulsive axon guidance protein, Neucrin