DRD2
Function
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
Post-translational modifications
Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Isoform 1
Expressed in the anterior pituitary gland.
Isoform 2
Expressed in the anterior pituitary gland.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Golgi apparatus membrane
- Multi-pass membrane protein
Alternative names
D(2) dopamine receptor, Dopamine D2 receptor, DRD2