DRD4

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

Polyubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex: polyubiquitination does not lead to degradation of DRD4 protein.

Palmitoylated. Palmitoylation of the C-terminal Cys is important for normal expression at the cell membrane.

Belongs to the G-protein coupled receptor 1 family.

Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.

• Cell membrane
• Multi-pass membrane protein

D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4

• entrezGene:1815
• omim:126452
• swissprot:P21917

Proteins

Neuroscience

43901Da