DRG2
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.
Post-translational modifications
Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.
Polyubiquitinated.
Sequence Similarities
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Tissue Specificity
Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
Developmentally-regulated GTP-binding protein 2, DRG-2, Translation factor GTPase DRG2, TRAFAC GTPase DRG2, DRG2