DSC1
Domain
Calcium may be bound by the cadherin-like repeats.
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Function
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation (By similarity). Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood (By similarity).
Tissue Specificity
Strongly expressed in epidermis, less in lymph node and tongue.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- Desmosome
Alternative names
CDHF1, DSC1, Desmocollin-1, Cadherin family member 1, Desmosomal glycoprotein 2/3, DG2/DG3