DTX1
Domain
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Function
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
Sequence Similarities
Belongs to the Deltex family.
Tissue Specificity
Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
Cellular localization
- Cytoplasm
- Nucleus
- Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Alternative names
E3 ubiquitin-protein ligase DTX1, Protein deltex-1, RING-type E3 ubiquitin transferase DTX1, Deltex1, hDTX1, DTX1