DTX4
Domain
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the Deltex family.
Cellular localization
- Cytoplasm
Alternative names
KIAA0937, RNF155, DTX4, E3 ubiquitin-protein ligase DTX4, Protein deltex-4, RING finger protein 155, RING-type E3 ubiquitin transferase DTX4, Deltex4