Dual specificity protein phosphatase CDC14B
Domain
Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Function
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Nucleoplasm
- Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
Alternative names
Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B, CDC14B