DUOX1
Developmental stage
Widely expressed in fetal tissues.
Function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
Post-translational modifications
N-glycosylated.
Sequence Similarities
In the N-terminal section; belongs to the peroxidase family.
Tissue Specificity
Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.
Cellular localization
- Apical cell membrane
- Multi-pass membrane protein
- Localizes to the apical membrane of epithelial cells.
Alternative names
DUOX, LNOX1, THOX1, DUOX1, Dual oxidase 1, Large NOX 1, Long NOX 1, NADPH thyroid oxidase 1, Thyroid oxidase 1