DUSP1

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

• Nucleus

CL100, MKP1, PTPN10, VH1, DUSP1, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, Protein-tyrosine phosphatase CL100, MAP kinase phosphatase 1, MKP-1

• entrezGene:1843
• omim:600714
• swissprot:P28562

Proteins

Oncology

39298Da