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DUSP14

Function

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation (PubMed:24403530).

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Alternative names

MKP6, DUSP14, Dual specificity protein phosphatase 14, MKP-1-like protein tyrosine phosphatase, Mitogen-activated protein kinase phosphatase 6, MKP-L, MAP kinase phosphatase 6, MKP-6

swissprot:O95147 entrezGene:11072 omim:606618