DUSP15
Function
May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).
Isoform 3
May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Tissue Specificity
Highly expressed in testis (PubMed:15138252). Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions (PubMed:22792334).
Cellular localization
- Cytoplasm
- Isoform 3
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
Alternative names
C20orf57, VHY, DUSP15, Dual specificity protein phosphatase 15, VH1-related member Y, Vaccinia virus VH1-related dual-specific protein phosphatase Y