DUSP18
Function
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Tissue Specificity
Widely expressed with highest levels in liver, brain, ovary and testis.
Cellular localization
- Cytoplasm
- Nucleus
- Mitochondrion inner membrane
- Peripheral membrane protein
- Intermembrane side
- Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.
Alternative names
LMWDSP20, DUSP18, Dual specificity protein phosphatase 18, Low molecular weight dual specificity phosphatase 20, LMW-DSP20