DUSP26
Function
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Tissue Specificity
Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
Cellular localization
- Cytoplasm
- Nucleus
- Golgi apparatus
Alternative names
DUSP24, LDP4, MKP8, NATA1, SKRP3, DUSP26, Dual specificity protein phosphatase 26, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, Mitogen-activated protein kinase phosphatase 8, Novel amplified gene in thyroid anaplastic cancer, DSP-4, LDP-4, MAP kinase phosphatase 8, MKP-8