DUSP3

Function

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439).

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Cellular localization

• Nucleus
• Cytoplasm
• Cytoskeleton
• Flagellum axoneme

Alternative names

VHR, DUSP3, Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase

Database links

swissprot:P51452 omim:600183 genbank:NP_004081.1 entrezGene:1845