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DUSP8

Function

Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Tissue Specificity

Abundant in brain, heart and skeletal muscle.

Cellular localization

Alternative names

C11orf81, VH5, DUSP8, Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5

swissprot:Q13202 entrezGene:1850 omim:602038