DVL2 phospho S143
Domain
The DIX domain mediates homooligomerization.
Function
Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Post-translational modifications
Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).
Ubiquitinated via 'Lys-63'-linked polyubiquitin chains; leading to its autophagy-mediated degradation.
Sequence Similarities
Belongs to the DSH family.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Cytosol
- Cytoplasmic vesicle
- Nucleus
- Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).
Alternative names
Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2