DYNC1I1
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Sequence Similarities
Belongs to the dynein intermediate chain family.
Cellular localization
- Cytoplasm
- Chromosome
- Centromere
- Kinetochore
- Cytoplasm
- Cytoskeleton
- Spindle pole
Alternative names
DNCI1, DNCIC1, DYNC1I1, Cytoplasmic dynein 1 intermediate chain 1, Cytoplasmic dynein intermediate chain 1, DH IC-1