DYNLRB2
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Sequence Similarities
Belongs to the GAMAD family.
Tissue Specificity
High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
DNCL2B, DNLC2B, ROBLD2, DYNLRB2, Dynein light chain roadblock-type 2, Roadblock domain-containing protein 2