DYNLT3
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
Sequence Similarities
Belongs to the dynein light chain Tctex-type family.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoskeleton
- Chromosome
- Centromere
- Kinetochore
- Colocalizes with BUB3 at kinetochores specifically during prometaphase.
Alternative names
TCTE1L, TCTE1XL, DYNLT3, Dynein light chain Tctex-type 3, Protein 91/23, T-complex-associated testis-expressed 1-like