Dystrobrevin beta
Domain
The coiled coil domain may mediate the interaction with dystrophin.
Function
Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity).
Post-translational modifications
Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A.
Sequence Similarities
Belongs to the dystrophin family. Dystrobrevin subfamily.
Tissue Specificity
Highly expressed in brain, kidney and pancreas.
Cellular localization
- Cytoplasm
- Postsynaptic density
- Cell projection
- Dendrite
- Basal cell membrane
- Postsynapse
- Nucleus
- Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells.
Alternative names
Dystrobrevin beta, DTN-B, Beta-dystrobrevin, DTNB