DZIP3

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.

Protein modification; protein ubiquitination.

Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.

• Cytoplasm

KIAA0675, DZIP3, E3 ubiquitin-protein ligase DZIP3, DAZ-interacting protein 3, RING-type E3 ubiquitin transferase DZIP3, RNA-binding ubiquitin ligase of 138 kDa, hRUL138

• entrezGene:9666
• swissprot:Q86Y13

Proteins

Epigenetics

138604Da