E

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by slowing down the cell secretory pathway (PubMed:33229438). May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes (PubMed:32891874).

Belongs to the betacoronaviruses E protein family.

• Host Golgi apparatus membrane
• Single-pass type III membrane protein
• The cytoplasmic tail functions as a Golgi complex-targeting signal.

4, E, Envelope small membrane protein, sM protein

• swissprot:P0DTC4

Proteins

Immunology & Infectious Disease

8365Da