Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Oxidation of Cys-340 in response to redox signaling leads to the loss of DNA-binding activity and the inactivation of gene activator or repressor function.
Phosphorylated.
Belongs to the papillomaviridae E2 protein family.
Regulatory protein E2, E2
Proteins
45450Da
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