E2F3

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Sequence Similarities

Belongs to the E2F/DP family.

Cellular localization

• Nucleus

Alternative names

KIAA0075, E2F3, Transcription factor E2F3, E2F-3

Database links

swissprot:O00716 entrezGene:1871 genbank:AAH16847 omim:600427