EAF2
Function
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Sequence Similarities
Belongs to the EAF family.
Tissue Specificity
Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes.
Cellular localization
- Nucleus speckle
Alternative names
TRAITS, BM-040, EAF2, ELL-associated factor 2, Testosterone-regulated apoptosis inducer and tumor suppressor protein