EAPP
Developmental stage
During the cell cycle, expression disappears during mitosis.
Function
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.
Tissue Specificity
Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
C14orf11, BM-036, EAPP, E2F-associated phosphoprotein