EBF1

Function

Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity).

(Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314).

Sequence similarities

Belongs to the COE family.

Cellular localization

• Nucleus

Alternative names

• COE1
• EBF
• EBF
• COE1
• EBF1
• Transcription factor COE1
• O/E-1
• OE-1
• Early B-cell factor

Database links

• entrezGene:1879
• omim:164343
• swissprot:Q9UH73

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

64464Da