JavaScript is disabled in your browser. Please enable JavaScript to view this website.

ECHDC1

Function

Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).

Sequence Similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

Cellular localization

Alternative names

Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD, ECHDC1

swissprot:Q9NTX5 omim:612136 entrezGene:55862