ECI1
Function
Key enzyme of fatty acid beta-oxidation (Probable). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (By similarity) (PubMed:7818490). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length (By similarity).
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Sequence Similarities
Belongs to the enoyl-CoA hydratase/isomerase family.
Tissue Specificity
Expressed in liver (at protein level).
Cellular localization
- Mitochondrion matrix
Alternative names
DCI, ECI1, Dodecenoyl-CoA isomerase