ECI2
Function
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Sequence Similarities
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Tissue Specificity
Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.
Cellular localization
- Isoform 1
- Mitochondrion
- Isoform 2
- Peroxisome matrix
Alternative names
DRS1, HCA88, PECI, ECI2, Enoyl-CoA delta isomerase 2, DRS-1, Diazepam-binding inhibitor-related protein 1, Dodecenoyl-CoA isomerase, Hepatocellular carcinoma-associated antigen 88, Renal carcinoma antigen NY-REN-1, DBI-related protein 1, pECI