Ecm1
Function
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity).
Tissue Specificity
Expressed in the surrounding connective tissues of developing long bones, but not in the cartilage. The long isoform is expressed in a number of tissues including liver, heart and lungs. The short isoform is expressed in skin and cartilage-containing tissues such as tail and front paw. No expression is found in brain.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Extracellular matrix protein 1, Secretory component p85, Ecm1