ECPAS
Function
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity).
Sequence Similarities
Belongs to the ECM29 family.
Cellular localization
- Endoplasmic reticulum
- Endoplasmic reticulum-Golgi intermediate compartment
- Endosome
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Nucleus
- Endosome
- Multivesicular body
- Cytoplasmic vesicle
Alternative names
ECM29, KIAA0368, ECPAS, Proteasome adapter and scaffold protein ECM29, Ecm29 proteasome adapter and scaffold, Proteasome-associated protein ECM29 homolog